Browsing by Author "Aydın, Hatip"

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Mutations in ANKLE2, a ZIKA Virus Target, Disrupt an Asymmetric Cell Division Pathway in Drosophila Neuroblasts to Cause Microcephaly

Link, Nichole; Chung, Hyunglok; Jolly, Angad; Withers, Marjorie A.; Tepe, Burak; Arenkiel, Benjamin R.; Shah, Priya S.; Krogan, Nevan J.; Aydın, Hatip; Geçkinli, Bilgen Bilge; Tos, Tülay; Işıkay, Şedat; Tüysüz, Beyhan; Mochida, Ganeshwaran H.; Thomas, Ajay X.; Clark, Robin Dawn; Mirzaa, Ghayda M.; Lupski, James R.; Bellen, Hugo J. (Cell Press, 2019-12-16)

The apical Par complex, which contains atypical protein kinase C (aPKC), Bazooka (Par-3), and Par-6, is required for establishing polarity during asymmetric division of neuroblasts in Drosophila, and its activity depends ...