<hr>Investigation of the efficacy of plantago major flavonoids in the healing of diabetic foot wound in silico analysis

Abstract

Diabetes is a chronic disease that is rapidly increasing worldwide due to insulin deficiency. Diabetic foot ulcer is one of the most important complications of diabetes. There are many synthetic and natural treatment methods in the treatment of these wounds. Among the possible side effects of synthetic drugs, the use of natural flavonoids such as Quercetin is preferred in the treatment of diabetic wounds. In this study, Plantago's major flavonoids, which can be an alternative to Quercetin, were investigated in silico. Whether Plantago major and its flavonoids show similar properties with Quercetin was investigated in silico with the help of AutoDockTools software. The ADME study of flavonoids was investigated with the help of SwissAdme, an open-access web tool. The results of the in silico study of Plantago major's flavonoids and Quercetin's 4ZZJ, one of the SIRT 1 receptors that play a role in diabetic wound healing; Plantago major flavonoids luteolin (-4.81 kcal.mol-1), apigenin (-4.74 kcal.mol-1) and Hispidulin (-4.58 kcal.mol-1) are better than Quercetin (-4.56 kcal.mol-1). showed that it has binding energy. In conclusion, this in silico study showed that Plantago major flavonoids luteolin, apigenin and hispidulin could be natural alternatives to Quercetin for diabetic wound healing.